T Lymphocytes in Autoimmune Disorders
Dr. Clark's laboratory is interested in the cell biology of the T lymphocyte, especially as it relates to autoimmune diseases. The immune response in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis, as well as animal models for these diseases are studied at the level of the T cell. The structure of the T cell antigen-receptor, T cell function and activation, and T cell migration and homing are studied using T cell cloning, T cell hybridoma production, molecular biological approaches, and monoclonal antibody technology. The understanding of basic T cell function as it relates to immune mediated pathology is the overall goal of his laboratory.
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