Regulation of Cell Growth
My lab is broadly interested in how
growth factors such as PDGF regulate cell growth. For several
years we have been working on how the c-fos
promoter is regulated. We discovered a growth factor inducible
called SIF which turns out to be composed of
STAT family transcription factors. We also
study the yeast pheromone response pathway
which is remarkably analogous to some
aspects of fos regulation. Recent attention has focussed on the role of TFII-I in c-fos regulation. We have also
been interested in the
c-myc gene and have recently found a novel myc interacting protein
using the yeast two-hybrid system. Other interests of the lab include
the development of new genetic strategies for studying mammalian
cells and elucidating the relationship between growth factor mediated signal transduction and the cell cycle
machinery. A new interest of the lab is the development of an annotated database of genes called MedStract in collaboration with a computational linguistics group at Brandeis.
Current projects include:
- Mechanism of activation of Stats by PDGF
- Regulation of c-fos by the Jak/Stat pathway
- Characterization of the myc interacting protein, Rht
- Activation of STATs by oxidative stress
- Role of Cdc37 in signal transduction and the cell cycle
- Role of TFII-I in c-fos regulation and signal transduction
- Development of the annotated gene database called
MedStract
|
Search: [ current | former scholar ] [ current | awarded institution ] [ quick search ]
