Signal Transduction Regulating Neuronal Gene Expression
In 1984 Greenberg and Ziff demonstrated that c-fos transcription is induced
very quickly after the stimulation of quiescent fibroblasts with serum or purified growth factors. Moreover, this
transcriptional response was remarkably transient, returning to virtually undetectable levels within an hour. He and
others quickly extended this observation to show that c-fos transcription could be induced by a wide variety of
stimuli in a plethora of cell types.
These properties of c-fos expression make it an excellent tool for addressing a number of interesting biological
questions. Among these are questions of how extracellular signals lead to changes in gene expression, how are these
changes in gene expression important for a cell, and what determines the rate at which an mRNA is degraded.
In recent years the lab has become more generally interested in issues of intracellular signal
transduction, and especially
in signal transduction in the nervous system. In addition, we have become more widely interested in the role of
transcription factors in controlling cell proliferation, differentiation, and death.
Additional information can be found on the [Greenberg Homepage] at Children's Hospital.
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