Rho-type GTPases control the spatial
organization of cytoskeletal and signaling proteins in eukaryotic
cells. Our lab is using the yeast Saccharomyces cerevisiae
to investigate the following questions concerning Rho-type GTPases:
- What are their targets and regulators?
- How do they choose among different
potential targets in different situations?
- How are they activated and localized
to the appropriate places at the correct times in the cell cycle?
- How are the actions of different Rho-type GTPases coupled?
The tools that we use to address these questions are
biochemistry, molecular biology, microscopy, genetics, and
two-hybrid analysis.
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