Professor
Kelleher is a bioanalytical chemist and is interested in
finding novel posttranslational modifications and
studying enzymatic mechanisms of large enzymes (>500
kDa). Using high-resolution mass spectrometry to
spearhead the research, we correlate protein
fragmentation data to fully sequenced genomes to scan for
chemically-altered gene products and the cellular
alteration machinery. Also, the biosynthesis of many
clinically-used drugs occurs on ultralarge enzymes acting
as solid supports for covalent catalysis, ideal for study
by mass spectrometry.
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