Research in
this laboratory focuses on many aspects of innate
immunity and includes the following areas: 1) Molecular
mechanisms of innate immune recognition: Identification
and analysis of receptors involved in innate immune
recognition and signaling pathways activated by these
receptors. The system of particular interest is the
recently identified family of Toll-like receptors, which
are conserved between mammals and insects. 2) Control of
the adaptive immune responses by innate immune
recognition. Signals induced upon innate immune
recognition (co-stimulatory molecules, cytokines and
chemokines) are necessary for the initiation and
differentiation of the adaptive immune responses. We are
interested in molecular mechanisms that allow translation
of the signals recognized by the Pattern Recognition
Receptors into activation of naive lymphocytes and their
differentiation into effector cells. 3) Mechanisms of
autoimmunity and allergy and new strategies for vaccine
design.
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