Biophysical Studies of Protein Folding and Studies of Protein Misfolding and Aggregation in Amyloid Diseases
The research in my group is oriented towards answering important biological questions that
concern the intimate behavior of proteins. The approach that we use is essentially
multidisciplinary. It includes a broad range of techniques and methodologies, such as
molecular biology, protein engineering and protein chemistry, steady state spectroscopy
(fluorescence, absorption, circular dichroism), nuclear magnetic resonance, kinetic
techniques (stopped-flow, continuous flow, temperature-jump), laser spectroscopy and
computational analysis. The scientific questions that we investigate can be divided into
three general areas: i) in vitro protein folding and design; ii) protein self-assembly and its
relationship with neurodegenerative diseases; iii) experimental and theoretical protein
evolution.
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