Molecular Basis for Synapse Formation in
the CNS
We are interested in the basic cell-biological mechanisms that lead
to the formation of the pre- and post- synaptic membrane specializations
in the central nervous system. Furthermore, we are studying signaling
events that regulate synaptogenesis and thereby generate specific
neuronal circuits during development.
We are using the mouse cerebellum as a model system. Our experimental
approach is a combination of cell-based in vitro assays, functional
imaging, biochemistry, and gene expression profiling to dissect the
molecular machinery and to isolate novel proteins with a function
in synapse formation.
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