Department of Chemistry
600 West Campus Drive, Room MIC 232
West Haven, CT 06516
2016 Searle Scholar
Post-transcriptional Regulation of Gene Expression
Gene expression is exquisitely tuned by post-transcriptional processes such as translation regulation and RNA turnover. We leverage tools from chemical biology and mass spectrometry-based proteomics to answer fundamental questions about post-transcriptional regulation, including (1) how ribosomes translate short open reading frames to produce currently non-annotated peptides; (2) how translation initiation site selection regulates and diversifies the proteome; and (3) how protein complexes degrade RNA to shut down gene expression. Our multidisciplinary approach will illuminate the "dark matter" of the genome and the mechanisms by which it is expressed into functional RNA and proteins.
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