George Barany

Research Interests

Biological Chemistry

• peptide synthesis, particularly the solid-phase method
• protecting groups for organic functionalities, with an emphasis on the concept of "orthogonality"
• chemistry of thiols, disulfides, and polysulfanes
• sulfurization reagents for synthetic antisense DNA and RNA
• functionalization of soluble and insoluble polymers
• elucidation of labile structures by mass spectrometry
• attack on problems of biological interest from a chemical angle
• pharmaceutical effects of garlic and onion constituents
• rational design of protein analogues with altered specificities
• mechanism of protein folding
• role of sugars, phosphates, and other posttranslational modifications for structure and function of peptide conjugates
• preparation of DNA and PNA arrays for detection of genetic diseases
• chemical combinatorial libraries