George Barany
Research Interests
Biological Chemistry
- peptide synthesis, particularly the solid-phase method
- protecting groups for organic functionalities, with an emphasis on the concept of "orthogonality"
- chemistry of thiols, disulfides, and polysulfanes
- sulfurization reagents for synthetic antisense DNA and RNA
- functionalization of soluble and insoluble polymers
- elucidation of labile structures by mass spectrometry
- attack on problems of biological interest from a chemical angle
- pharmaceutical effects of garlic and onion constituents
- rational design of protein analogues with altered specificities
- mechanism of protein folding
- role of sugars, phosphates, and other posttranslational modifications for structure and function of peptide conjugates
- preparation of DNA and PNA arrays for detection of genetic diseases
- chemical combinatorial libraries