Jean S. Baum
NMR Studies on BiopolymersOur research involves the development and application of nuclear magnetic resonance (NMR) spectroscopy to the study of biopolymers. Methods of high-resolution 2-D NMR in conjunction with computer algorithms are used to examine the dynamics and three-dimensional structures of proteins in solution.
One area of interest is using NMR to understand the manner in which a protein folds from an unstructured state to its final compact globular structure. The direct study of the folding intermediates may provide a description of the pathways by which this important process occurs. A second area of interest involves issues of protein-protein interaction and molecular recognition in proteins of medical and biological interest. The emphasis of the research is to develop novel NMR methods and apply existing techniques to model peptide and protein systems in order to explore these problems in biophysical chemistry.