Neil Ganem

Scholar: 2015

Awarded Institution
Assistant Professor
Boston University
Dept of Pharmacology and Medicine, Division of Hematology & Oncology


Research Interests

Defining the Causes and Consequences of Chromosome Instability


Chromosome instability (CIN), broadly defined as the persistent gain or loss of whole chromosomes, is a hallmark of solid tumors and is known to facilitate tumor initiation, progression, and relapse. Consequently, CIN confers poor clinical prognosis. The development of CIN in cancer cells requires two distinct steps. First, genetic or cell biological defects that induce abnormal chromosome segregation and aneuploidy must arise within cells. Second, cells must adapt to overcome the tumor suppression mechanisms that normally act to restrain the proliferation of such genetically abnormal cells.

We use a combination of high-resolution microscopy, cell biology, genome-wide screening, and bioinformatics to mechanistically understand both the causes and consequences of chromosome instability in human cancer cells. A long-term goal of our work is to identify new therapeutic avenues that selectively kill abnormal, chromosomally unstable cancer cells while sparing the normal cells from which they originated.