Board Member: 2017 - Present
Dr. Schwartzberg's lab team studies signal transduction in T lymphocytes, with a particular focus on signaling molecules that affect T lymphocyte function and their ability to respond to infection. Her group generates mouse models that lack genes affecting a variety of signaling molecules to see how the loss of a particular gene affects the immune system.
They have generated mouse models that "knockout" genes involved in or related to several primary human immunodeficiency syndromes, including X-linked lymphoproliferative syndrome and X-linked agammaglobulinemia. They challenge these knockout mouse models with a wide array of infectious agents, including parasites, to study the effect of the loss of gene function on the overall immune system in vivo and to analyze cells from the animals in vitro to examine what has happened at both a biochemical and cellular level. Dr. Schwartzberg’s research not only helps explain what is going wrong in human immune diseases but also advances basic scientific understanding of immune system function in general and identifies likely pathways for therapeutic research.